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Updated: Jun 15, 2026
04:38
A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
Does prestroke depression impact poststroke depression and treatment?
L Douglas Ried1, Huanguang Jia, Randi Cameon
1Malcom Randall Veterans Affairs Medical Center, Gainsville, FL, USA. Doug.Ried@swosu.edu
Summary
Depression before stroke significantly predicts post-stroke depression (PSD). Prior depression also influences serotonin selective reuptake inhibitor (SSRI) prescribing patterns, suggesting early intervention may be considered.
Area of Science:
- Neurology
- Psychiatry
- Public Health
Background:
- Post-stroke depression (PSD) is a common and debilitating complication.
- Understanding the prevalence of depression before and after stroke is crucial for effective management.
- Serotonin selective reuptake inhibitor (SSRI) use patterns warrant investigation in this population.
Purpose of the Study:
- To determine the prevalence of depression before stroke (BSD) and post-stroke depression (PSD).
- To analyze serotonin selective reuptake inhibitor (SSRI) treatment patterns in veterans following a stroke.
Main Methods:
- Retrospective cohort study design.
- Utilized data from the Veterans Healthcare System.
- Included 790 veterans with confirmed stroke, analyzing depression diagnoses and SSRI dispensing before and after stroke.
Main Results:
- Nearly 10% of veterans had depression before stroke (BSD), increasing to nearly 26% after stroke (PSD).
- Veterans with BSD were significantly more likely to be diagnosed with PSD (OR = 9.5).
- SSRI use before stroke predicted later SSRI use (OR = 31.9), with nearly 32% of all veterans dispensed an SSRI.
Conclusions:
- Pre-stroke depression status is a key predictor of PSD.
- Provider prescribing behavior for SSRIs is influenced by pre-stroke depression.
- Findings suggest a trend towards prophylaxis or early treatment for PSD, though not yet standard practice.
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