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Updated: Jun 15, 2026

06:24
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
[Sex reassignment surgery in transsexuals]
Kim Alexander Tønseth1, Therese Bjark, Gunnar Kratz
1Plastikkirurgisk avdeling, Oslo universitetssykehus, Rikshospitalet 0027 Oslo, Norway. kim.tonseth@rikshospitalet.no
Summary
Sex reassignment surgery involves detailed psychiatric and endocrine evaluations before genital and breast procedures. This includes constructing new genitalia and augmenting breasts for transgender individuals.
Area of Science:
- Medical Science
- Surgical Procedures
- Endocrinology
Background:
- Rikshospitalet serves as Norway's national center for treating transsexual patients.
- Annually, 50-70 patients undergo assessment, with approximately 20 diagnosed as transsexual.
- Around 15 individuals per year proceed to sex reassignment surgery after hormone therapy.
Purpose of the Study:
- To outline the diagnostic criteria for transsexualism.
- To detail the surgical procedures for sex reassignment.
- To emphasize the surgical aspects of gender affirmation.
Main Methods:
- The study is based on a non-systematic literature review.
- Clinical experience from Rikshospitalet is incorporated.
- Patient evaluation protocols for surgery are described.
Main Results:
- Surgical candidates require at least one year of psychiatric evaluation and one year of endocrine treatment.
- Male-to-female surgery may include breast augmentation and genital construction (neovagina, neoclitoris).
- Female-to-male surgery options include breast reduction, hysterectomy, and neopenis construction (metaidoioplasty or phalloplasty).
Conclusions:
- Sex reassignment surgery primarily involves procedures on the breasts and genitalia.
- Surgical outcomes are contingent on patient response to hormone therapy and specific procedures chosen.
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Artificial transdifferentiation occurs...
Artificial transdifferentiation occurs...

