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Updated: Jun 15, 2026

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
Published on: January 13, 2023
A new protocol in photodynamic therapy: enhanced tumour cell death by combining two different photosensitizers
Angeles Villanueva1, Juan Carlos Stockert, Magdalena Cañete
1Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Darwin 2, Edificio de Biología. E-28049, Madrid, Spain. angeles.villanueva@uam.es
Abstract:
The combined application of two photosensitisers (PSs), zinc(II) phthalocyanine (ZnPc) and the cationic porphyrin meso-tetrakis(4-N-methylpyridyl)porphine (T4MPyP), on HeLa cells produced an enhanced lethal effect relative to treatments with single PSs. Thus, the proper combination of PSs may constitute a new strategy to improve the efficacy of clinical photodynamic therapy.

