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Activity of the human carcinogen MeCCNU in the mouse bone marrow micronucleus assay
1ICI Central Toxicology Laboratory, Alderley Park Macclesfield, Cheshire, United Kingdom.
Environmental and Molecular Mutagenesis
|January 1, 1991
Abstract:
The nitrosourea mustard MeCCNU is the most recent organic chemical to be classified as a human carcinogen by IARC. MeCCNU gave a strong positive response when tested in the mouse bone marrow micronucleus assay. Activity was evident using either ip injection or oral gavage of the test chemical. These results further support the correlation between human carcinogens and their genotoxicity.