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Updated: Jun 15, 2026

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
[Steroidal alkaloids of from Veratrum dahuricum]
Lang Zhao1, Zhiqiang Ou, Kan Wang
1State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Objective:
To study the steroidal alkaloids in Veratrum dahuricum.
Method:
The compounds were isolated and purified by various column chromatographic methods. Their structures were identified by spectroscopic analysis.
Result:
Five compounds were isolated and identified as (20R, 22S, 25S)-veratra-5,13-dien-3beta-ol (1), angeloylzygadenine (2), 15-O-(2-methylbutanoyl)-3-O-veatroylprotoverine (3), 20-isoveratramine (4), veratramine (5).
Conclusion:
Compound 1 was a new compound, compounds 24 were obtained from the plant for the first time.
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