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Published on: December 14, 2021
[Pharmacokinetics of fangchinoline and tetrandrine in rats]
Zhonghong Li1, Xialei Fan, Meiming Cai
1Jiangsu Institute for Food and Drug Control, Nanjing 210008, China. lizhh402@sohu.com
Objective:
To investigate the pharmacokinetics profile of fangchinoline and tetrandrine in rats after administration of single compound and mixture with other intergradient in traditional prescription.
Method:
A method for determination of fangchinoline and tetrandrine in rat plasma by using HPLC-MS has been developed and validated. The pharmacokinetics of two compounds and two compounds in the effective component group (ECG) of Xiaoxuming decoction were compared.
Result:
Compared with the single dose of compound experiment results, the t(max) of fangchinoline and tetrandrine were longer than those in the single dose of ECG experiment. At the meanwhile the rest parameter showed no significant difference.
Conclusion:
Other components in the ECG of Xiaoxuming decoction delayed the absorption rate of fangchinoline and tetrandrine, the bioavailability of two compounds were the same as that of the single dose of compound experiment.
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