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Updated: Jun 15, 2026

High-resolution Tandem Mass Spectrometry for Studying Chemical Constituents of Gynura bicolor DC
Published on: February 2, 2024
Highly acylated diterpenoids with a new 3,4-secograyanane skeleton from the flower buds of Rhododendron molle
Sujuan Wang1, Sheng Lin, Chenggen Zhu
1Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing 100050, People's Republic of China.
Abstract:
Four highly acylated diterpenoids with a new 3,4-secograyanane skeleton, secorhodomollolides A-D (1-4), have been isolated from the flower buds of Rhododendron molle. Their structures including absolute configurations were determined on the basis of spectroscopic data interpretation and single-crystal X-ray crystallography. Compound 4 exhibited significant analgesic and sedative effects at a dose of 5 mg/kg, and compound 2 showed selective cytotoxic activity against human hepatoma carcinoma cell line (Bel-7402) with IC(50) 0.97 microM.
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