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Therapeutic donor insemination: a prospective randomized study of scheduling methods
R R Odem1, N M Durso, C A Long
1Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis 63110.
Fertility and Sterility
|May 1, 1991
Summary
Basal body temperature (BBT) graph interpretation is more effective than urinary luteinizing hormone (LH) monitoring for scheduling therapeutic donor insemination. BBT graphing resulted in higher pregnancy rates and lower costs.
Area of Science:
- Reproductive Endocrinology
- Infertility Treatment
- Assisted Reproductive Technologies
Background:
- Therapeutic donor insemination (TDI) requires precise timing for optimal success.
- Both basal body temperature (BBT) graphing and urinary luteinizing hormone (LH) monitoring are methods used to predict ovulation for timed insemination.
- Comparing the efficacy and cost-effectiveness of these two methods is crucial for clinical practice.
Purpose of the Study:
- To compare the effectiveness of basal body temperature (BBT) graphs versus urinary luteinizing hormone (LH) monitoring in scheduling therapeutic donor insemination.
- To evaluate fecundity rates, cumulative pregnancy rates, and cost per pregnancy for each method.
Main Methods:
- A prospective randomized study design was employed.
- Participants were assigned to either the BBT or LH monitoring group.
- BBT graphs were physician-interpreted, while LH group patients monitored urine samples for ovulation surges.
Main Results:
- The 6-month cumulative pregnancy rate was significantly higher in the BBT group (65.1%) compared to the LH group (36.3%).
- The total cost per pregnancy was substantially lower in the BBT group ($3,997) versus the LH group ($6,212).
Conclusions:
- Basal body temperature (BBT) graphing offers significant therapeutic advantages for scheduling therapeutic donor insemination.
- Utilizing BBT graphs for scheduling TDI presents considerable economic benefits compared to LH monitoring.