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Updated: Jun 15, 2026

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition
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Patterned multiplex pathogen DNA detection by Au particle-on-wire SERS sensor.

Taejoon Kang1, Seung Min Yoo, Ilsun Yoon

  • 1Department of Chemistry, KAIST, Daejeon, Korea.

Nano Letters
|March 13, 2010
PubMed
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A novel gold nanoparticle-on-wire system enables specific, sensitive, and multiplex DNA detection. This advanced biosensor accurately identifies bacterial DNA, paving the way for improved infectious disease diagnostics.

Area of Science:

  • Nanotechnology
  • Biosensing
  • Molecular Diagnostics

Background:

  • Developing specific and sensitive DNA sensors is crucial for accurate disease diagnosis.
  • Multiplex detection of various DNA targets simultaneously remains a challenge in diagnostics.

Purpose of the Study:

  • To develop a gold nanoparticle-on-wire system for specific, sensitive, and multiplex DNA sensing.
  • To demonstrate the system's capability in identifying bacterial DNA for infectious disease diagnostics.

Main Methods:

  • Fabrication of a gold nanoparticle-on-wire system with patterned gold nanowires.
  • Utilizing the system for quantitative, multiplex DNA detection.
  • Testing the sensor with target DNAs from reference bacteria and clinical isolates.

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A Polyaniline-based Sensor of Nucleic Acids
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Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules
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Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules

Published on: June 1, 2011

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Last Updated: Jun 15, 2026

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition
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Published on: February 9, 2024

A Polyaniline-based Sensor of Nucleic Acids
07:58

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules
13:15

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules

Published on: June 1, 2011

Main Results:

  • The developed system functions as a specific, sensitive, and multiplex DNA sensor.
  • Multiplex DNA sensing was achieved quantitatively with a detection limit of 10 pM.
  • Successful identification of target bacterial DNAs from various sources.

Conclusions:

  • The gold nanoparticle-on-wire system offers a promising platform for advanced DNA sensing.
  • This technology enables precise identification of infectious agents, supporting clinical diagnostics.