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Related Concept Videos

Ribozymes02:47

Ribozymes

The term ribozyme is used for RNA that can act as an enzyme. Ribozymes are mainly found in selected viruses, bacteria, plant organelles, and lower eukaryotes. Ribozymes were first discovered in 1982 when Tom Cech’s laboratory observed Group I introns acting as enzymes. This was shortly followed by the discovery of another ribozyme, Ribonulcease P, by Sid Altman’s laboratory. Both Cech and Altman received the Nobel Prize in chemistry in 1989 for their work on ribozymes.
Ribozymes can be...

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DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition
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Published on: February 9, 2024

Nanomaterials based on DNA.

Nadrian C Seeman1

  • 1Department of Chemistry, New York University, New York, New York 10003, USA. ned.seeman@nyu.edu

Annual Review of Biochemistry
|March 13, 2010
PubMed
Summary
This summary is machine-generated.

Structural DNA nanotechnology uses branched DNA and cohesion for self-assembly. This enables the creation of DNA-based materials, including polyhedrons, crystals, and nanomechanical devices.

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Area of Science:

  • Biotechnology and Nanotechnology
  • Materials Science

Background:

  • Structural DNA nanotechnology has advanced significantly over 30 years.
  • It relies on combining synthetic stable branched DNA with sticky-ended cohesion.
  • Self-assembly protocols are central to constructing novel DNA-based materials.

Purpose of the Study:

  • To explore the capabilities of DNA self-assembly in creating complex nanostructures.
  • To highlight the versatility of DNA as a building material for nanotechnology.
  • To showcase advancements in DNA-based nanomechanical devices.

Main Methods:

  • Utilizing branched DNA molecules for self-assembly into specific shapes like polyhedrons.
  • Employing stiffer branched motifs to form periodic 2D and 3D DNA lattices (crystals).
  • Designing and integrating sequence-dependent nanomechanical devices driven by nucleotide pairing.

Main Results:

  • Successful construction of DNA polyhedrons with double helical edges and branched vertices.
  • Formation of self-assembled 2D and 3D periodic DNA crystals.
  • Development of DNA nanomechanical devices, including shape-changing molecules and DNA walkers.
  • Integration of devices into 2D DNA arrangements with sequence-dependent operation.

Conclusions:

  • DNA self-assembly, through branched structures and cohesion, is a powerful tool for creating diverse nanomaterials.
  • DNA nanotechnology enables the fabrication of complex architectures from simple molecular components.
  • The field has produced sophisticated nanomechanical devices with potential for advanced applications.