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Impact of leptin and leptin-receptor gene polymorphisms on serum lipids in Japanese obese children

T Okada1, T Ohzeki, Y Nakagawa

  • 1Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan. tomokada@med.nihon-u.ac.jp

Acta Paediatrica (Oslo, Norway : 1992)
|March 13, 2010
PubMed

Insights

Leptin receptor (LEPR) gene variants, specifically Lys109Arg and Ser343Ser, are linked to altered serum lipid profiles and body weight in obese Japanese children. Leptin gene polymorphisms showed no such associations.

Area of Science:

  • Genetics
  • Pediatrics
  • Metabolic Disorders

Background:

  • Leptin plays a role in regulating body weight and metabolism.
  • Serum lipid profile is a critical indicator of cardiovascular health.
  • Obesity in children is associated with dyslipidemia and increased health risks.

Purpose of the Study:

  • To investigate the association between serum lipids and polymorphisms in the leptin and leptin receptor (LEPR) genes in obese Japanese children.
  • To explore the relationship between these gene variations and anthropometric measurements.

Main Methods:

  • A cohort of 136 obese Japanese children (aged 5-17) was studied.
  • Polymorphisms in the leptin gene [(+19)A>G, (-2548)G>A, (-188)C>A, (-633)C>T] and LEPR gene [Lys109Arg, Gln223Arg, Pro1019Pro, Ser343Ser] were analyzed using PCR-RFLP.
  • Serum lipid profiles and relative weight were measured.

Main Results:

  • No significant associations were found between leptin gene polymorphisms and serum lipid profiles.
  • LEPR gene polymorphisms Lys109Arg and Ser343Ser showed significant associations with lipid profiles.
  • Arg109Arg homozygotes had lower total and LDL cholesterol, while Ser343Ser homozygotes had lower TG levels.
  • LEPR gene polymorphisms were also associated with relative weight.

Conclusions:

  • LEPR gene polymorphisms, particularly Lys109Arg and Ser343Ser, may influence serum lipid profiles in obese children.
  • These findings suggest a potential genetic contribution of the LEPR gene to lipid metabolism in pediatric obesity.
Abstract

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