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Updated: Jun 15, 2026

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury
Published on: March 26, 2019
Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury
Georgene W Hergenroeder1, Anthony N Moore, J Philip McCoy
1The Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas, USA. Georgene.W.Hergenroeder@uth.tmc.edu
Background:
Increased intracranial pressure (ICP) is a serious, life-threatening, secondary event following traumatic brain injury (TBI). In many cases, ICP rises in a delayed fashion, reaching a maximal level 48-96 hours after the initial insult. While pressure catheters can be implanted to monitor ICP, there is no clinically proven method for determining a patient's risk for developing this pathology.
Methods:
In the present study, we employed antibody array and Luminex-based screening methods to interrogate the levels of inflammatory cytokines in the serum of healthy volunteers and in severe TBI patients (GCS
Results:
Consistent with previous reports, we observed sustained increases in IL-6 levels in TBI patients irrespective of their ICP status. However, the group of patients who subsequently experienced ICP >or= 25 mm Hg had significantly higher IL-6 levels within the first 17 hours of injury as compared to the patients whose ICP remained
Conclusions:
Our results suggest that serum IL-6 can be used for the differential diagnosis of elevated ICP in isolated TBI.
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