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Related Experiment Video

Updated: Jun 15, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Viral hepatitis.

Geraldine M McQuillian¹, Deanna Kruszon-Moran, Maxine M Denniston

¹Centers for Disease Control and Prevention National Center for Health Statistics 3311 Toledo Road, Hyattsville, Maryland 20782, USA.

NCHS Data Brief

|March 13, 2010

Summary

Hepatitis A immunity increased in US-born children but decreased in older adults. Hepatitis B vaccination rates are high, and Hepatitis C infection prevalence has declined, though it remains higher in non-Hispanic Black populations.

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Area of Science:

Epidemiology
Infectious Diseases
Public Health

Background:

Viral hepatitis poses a significant public health challenge.
Understanding trends in hepatitis A, B, and C prevalence is crucial for targeted interventions.

Purpose of the Study:

To analyze recent trends in the prevalence of hepatitis A, B, and C infections and immunity in the United States.
To identify demographic shifts in infection rates and vaccination coverage.

Main Methods:

Analysis of seroprevalence data for hepatitis A, B, and C.
Examination of vaccination records for hepatitis B vaccine.
Stratification of data by age, sex, and race/ethnicity.

Main Results:

Hepatitis A antibody prevalence increased in US-born individuals aged 6-19, while decreasing in those 40 and older.
Hepatitis B virus (HBV) infection decreased in children aged 6-19, with over 90% receiving the vaccine by 2003-2006.
Hepatitis C virus (HCV) infection prevalence declined among high-risk groups, but remains higher in non-Hispanic Black populations, with a peak prevalence shift to those aged 40-49.

Conclusions:

Vaccination programs have impacted HBV infection rates in younger populations.
Shifting demographics of HCV infection highlight the need for continued surveillance and targeted prevention strategies.
Age-related trends in hepatitis A immunity suggest waning immunity in older cohorts.