A dual role for hippocampal replay
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Updated: Jun 15, 2026

Dual Extracellular Recordings in the Mouse Hippocampus and Prefrontal Cortex
Published on: February 16, 2024
Dori Derdikman1, May-Britt Moser
1Kavli Institute for Systems Neuroscience and the Centre for the Biology of Memory, Norwegian University of Science and Technology, N-7489, Trondheim, Norway. dori.derdikman@ntnu.no
Abstract:
Hippocampal place cells are active when the rat is at certain locations. The sequence of these active place cells is known to be rapidly replayed during sharp-wave-ripple events in the EEG. In this issue of Neuron, a study by Gupta et al. challenges previous notions that the replayed trajectories are solely a passive echo of past episodes. Rather, replay might also be an active process constructing a Tolmanian cognitive map of space, which makes flexible navigation possible.
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