Related Experiment Video
Updated: Jun 15, 2026
Isolation and Characterization of the Murine Uterosacral Ligaments and Pelvic Floor Organs
Published on: March 3, 2023
Is laminin gamma-1 a candidate gene for advanced pelvic organ prolapse?
Chen Chen1, Lori D Hill, Christine M Schubert
1Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, VA, USA.
Objective:
We sought to determine allele frequencies of 3 LAMC1 single nucleotide polymorphisms (SNPs) in Caucasian and African American (AA) women with stage>II pelvic organ prolapse (POP) (cases) and in ethnicity-matched controls with stage
Study Design:
Allelic discrimination was performed for LAMC1 SNPs rs10911193 (C/T), rs20563 (A/G), and rs20558 (T/C). SNP and haplotype-specific tests were used to examine associations among POP, ethnicity, and LAMC1.
Results:
In all, 411 women were enrolled. Significant differences in allele and haplotype frequencies existed among AAs and Caucasians: rs10911193 "T" (P=.0014); rs20563 "G" (P<.0001); rs20558 "C" (P<.0001); rs20563, rs20558 "GC" (P<.0001); and rs20563, rs20558 "AT" (P<.0001). No significant associations between POP and LAMC1 SNPs or haplotypes were found within ethnicities.
Conclusion:
While significant differences were identified between AA and Caucasian women, no associations were found between any LAMC1 gene variant and advanced POP.
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