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Updated: Jun 15, 2026
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Arterial Pouch Microsurgical Bifurcation Aneurysm Model in the Rabbit
Published on: May 14, 2020
Five-year follow-up in elastase-induced aneurysms in rabbits
1Neuroradiology Research Laboratory, Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA.
AJNR. American Journal of Neuroradiology
|March 13, 2010
Summary
Elastase-induced aneurysms in rabbits showed high patency rates for up to five years. Researchers noted significant mortality unrelated to aneurysms in long-term studies.
Area of Science:
- Vascular biology and experimental surgery
- Animal models for cardiovascular research
Background:
- Limited data exists on the long-term patency of elastase-induced aneurysms.
- The elastase-induced aneurysm model is crucial for studying aneurysm development and treatment.
Purpose of the Study:
- To evaluate aneurysm patency rates up to 5 years in a rabbit model.
- To provide data for long-term experimental aneurysm studies.
Main Methods:
- Twenty-five elastase-induced aneurysms were created in New Zealand white rabbits.
- Digital subtraction angiography (DSA) assessed patency and dimensions at 1 month, 2 years, and 5 years.
- Survival rates and aneurysm characteristics were analyzed.
Main Results:
- 11 of 12 aneurysms (92%) in surviving rabbits remained patent for 5 years.
- One narrow-neck aneurysm exhibited partial thrombosis.
- 52% of rabbits died from causes unrelated to the induced aneurysms.
Conclusions:
- Experimental aneurysms in rabbits demonstrate sustained patency for up to 5 years.
- High mortality rates unrelated to aneurysm pathology should be anticipated in long-term rabbit studies.
