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Long-term aspirin and clopidogrel response evaluated by light transmission aggregometry, VerifyNow, and

Esben Hjorth Madsen1, Jacqueline Saw, Søren Risom Kristensen

  • 1Department of Clinical Biochemistry, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark. ehmadsen@gmail.com

Clinical Chemistry
|March 13, 2010
PubMed

Insights

Identifying low platelet response to aspirin and clopidogrel requires reliable tests. Different platelet function tests yield variable results, impacting clinical decisions for patients on dual antiplatelet therapy.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Clinical Diagnostics

Background:

  • Reduced response to aspirin and clopidogrel is linked to ischemic events.
  • Reliable platelet function tests are crucial for identifying non-responders.
  • This study compared three platelet function tests during dual antiplatelet therapy.

Purpose of the Study:

  • To compare the performance of three different platelet function tests.
  • To assess the reliability of these tests in identifying low responders to aspirin and clopidogrel.
  • To evaluate test variability over one year in patients receiving dual antiplatelet therapy.

Main Methods:

  • Light transmission aggregometry (LTA), VerifyNow assay, and thrombelastography (TEG) were used.
  • Tests were performed on blood samples collected five times over one year.
  • Patients received aspirin (325 mg/day) and clopidogrel (75 mg/day) post-percutaneous coronary intervention.

Main Results:

  • Low response to clopidogrel varied in frequency and detection depending on the test method.
  • Moderate correlation was observed between LTA (ADP) and VerifyNow (P2Y12), but poor correlation with TEG (ADP).
  • Low aspirin response was detected by VerifyNow (AA) and TEG (AA) but rarely by LTA (AA).

Conclusions:

  • The method used significantly influences the detection of low clopidogrel response.
  • The best test for predicting ischemic events remains undetermined.
  • Low aspirin response is infrequent with AA-dependent methods; patient response can fluctuate over time.
Abstract

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