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Updated: Jun 15, 2026

In Vivo Vascular Permeability Detection in Mouse Submandibular Gland
Published on: August 4, 2022
Morpho-physiological approach to the paracellular route for salivary secretion by isolated perfused submandibular
Masataka Murakami1, Sadamitsu Hashimoto, Muxin Wei
1Nano-structure Physiology, National Institute for Physiological Sciences, OIB, National Institutes of Natural Sciences, Myoudaiji, Okazaki, Japan.
Abstract:
A part of the salivary components are shifted from the blood via a trans- and/or paracellular route. The isolated, arterially perfused, salivary glands (submandibular and parotid glands) were used to assess paracellular transport functionally and morphologically. In the present study, the hydrostatic pressure of the perfusion was changed and the fluid secretion and paracellular transport of fluorescent dye in the isolated perfused submandibular gland were examined. The present findings lead to the conclusion that part of the paracellular transport could be driven by hydrostatic pressure, and that fluid movement drags the solutes.
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