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Does hypothyroidism affect gastrointestinal motility?

Olga Yaylali¹, Suna Kirac, Mustafa Yilmaz

¹Department of Nuclear Medicine, Faculty of Medicine, Pamukkale University, Doktorlar Caddesi no. 42, Denizli 20100, Turkey. olgataskaya@yahoo.com

Gastroenterology Research and Practice

|March 13, 2010

Summary

This summary is machine-generated.

Hypothyroidism significantly slows esophageal transit and gastric emptying, indicating reduced gastrointestinal motor function in patients with this endocrine disorder.

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Gastrointestinal Motility Monitor (GIMM)

Gastrointestinal Motility Monitor (GIMM)

Published on: December 1, 2010

Area of Science:

Endocrinology
Gastroenterology
Medical Imaging

Background:

Thyroid hormones critically influence gastrointestinal (GI) motility.
Hypothyroidism, a condition of insufficient thyroid hormone production, may disrupt normal GI function.

Purpose of the Study:

To investigate the impact of primary hypothyroidism on esophagogastric motor functions.
To determine if hypothyroidism is associated with impaired esophageal and gastric motility.

Main Methods:

Esophagogastric endoscopy and scintigraphy were performed on 30 female patients with hypothyroidism and 10 healthy controls.
Dynamic esophageal scintigraphy assessed esophageal transit time.
Static gastric scintigraphy evaluated gastric emptying time.

Main Results:

Patients with hypothyroidism exhibited significantly prolonged esophageal transit time (52.56 sec vs. 24.30 sec, P=.02).
Gastric emptying time was also markedly increased in the hypothyroid group (49.06 min vs. 30.4 min, P=.01).

Conclusions:

Primary hypothyroidism significantly impairs esophageal and gastric motor activity.
Reduced GI motility in hypothyroidism can lead to gastrointestinal dysfunction.