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Related Concept Videos

Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
Sensory Functions of the Skin01:16

Sensory Functions of the Skin

The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
Introduction to Sensory Receptors01:31

Introduction to Sensory Receptors

Sensory receptors are vital in our ability to perceive and interpret the world. Sensory receptors are specialized cells in the peripheral nervous system that respond to various stimuli and enable one to experience different sensations. Based on specific criteria, sensory receptors are classified into distinct types.
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Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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Exocrine glands are those that release their secretions through ducts. Based on their mode of secretion, they can be classified into merocrine, apocrine, and holocrine.
Merocrine Secretion
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Detection of Ligand-activated G Protein-coupled Receptor Internalization by Confocal Microscopy
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Published on: April 9, 2017

Sebaceous gland receptors.

Christos C Zouboulis

    Dermato-Endocrinology
    |March 13, 2010
    PubMed
    Summary

    Human sebocytes express a wide array of receptors, including serpentine, single-transmembrane, and nuclear types. These receptor-ligand interactions are crucial for controlling sebocyte proliferation, differentiation, and lipid synthesis.

    Area of Science:

    • Dermatology and Cell Biology
    • Molecular Endocrinology
    • Biochemistry

    Background:

    • Human sebocytes are metabolically active cells crucial for skin homeostasis.
    • These cells express a diverse range of cell surface and intracellular receptors.
    • Receptor-ligand interactions play a fundamental role in cellular signaling and function.

    Purpose of the Study:

    • To comprehensively catalog the receptor repertoire of human sebocytes.
    • To elucidate the types of receptors expressed by sebocytes.
    • To understand the role of receptor-ligand interactions in sebocyte biology.

    Main Methods:

    • Bioinformatic analysis of sebocyte transcriptomic data.
    • Literature review of known receptor expression in human sebocytes.
    Keywords:
    hormonehumanreceptorsebaceous glandsebocytesskin

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  • Classification of identified receptors based on established signaling pathways.

    • Main Results:

    • Human sebocytes express multiple serpentine receptors (e.g., CRHR1/2, MC1R/5R, MOR, VPACRs, CNR1/2, VEGFR, HRH1).
    • Single-transmembrane receptors like IGF-IR and growth factor receptors are present.
    • Nuclear receptors (e.g., AR, PR, ERα/β, RARα/γ, RXRα/β/γ, VDR, PPARα/δ/γ, LXRα/β) and ion channels (e.g., TRPV1) are expressed.

    Conclusions:

    • Human sebocytes possess an extensive and complex receptor landscape.
    • The identified receptors mediate critical functions including proliferation, differentiation, and lipid synthesis.
    • Understanding this receptor network offers potential therapeutic targets for sebaceous gland-related conditions.