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Development of acute lympboblastic leukemia in a patient with increased hematogones after toxic bone marrow damage

Stefan Gattenlöhner1, Hermann Einsele

  • 1Institute of Pathology, University of Würzburg, Würzburg, Germany. stefan.gattenloehner@mail.uni-wuerzburg.de

International Journal of Clinical and Experimental Pathology
|March 13, 2010
PubMed

To the best of our knowledge we describe the first case showing the association of increased B cell precursors/hematogones in a regenerating post-toxic bone marrow with subsequent development of a B-ALL. Since all immunohistochemical/moleculargenetic anaylses have failed to identify the initial malignant leukemic clone, we suggest a close-meshed follow-up of such cases to identify potential mechanisms for the malignant transformation of B-cell precursors/hematogones and to prevent further fatal courses.

Keywords:
B-ALLBone marrowhematogonestoxic damage

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