Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Papillary Dermis

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

Reticular Dermis

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ubiquitin and ubiquitin conjugates in human lens.

Experimental eye research·1992

Same author

Evidence for increased prevalence of SRY mutations in XY females with complete rather than partial gonadal dysgenesis.

American journal of human genetics·1992

Same author

Systemic distribution of wear debris after hip replacement. A cause for concern?

The Journal of bone and joint surgery. British volume·1992

Same author

Estimates of HIV infection among injecting drug users in Glasgow, 1985-1990.

AIDS (London, England)·1992

Same author

The classification of afferents from muscle spindles of the jaw-closing muscles of the cat.

The Journal of physiology·1992

Same author

The effect of succinylcholine on cat gastrocnemius muscle spindle afferents of different types.

The Journal of physiology·1992

Same journal

Fatal Rhinocerebral Mucormycosis and <i>Aspergillus flavus</i> Coinfection Complicated by Internal Carotid Artery Arteritis: A Case Report.

Case reports in medicine·2026

Same journal

A Case of Strabismus in a Patient With Psoriasis.

Case reports in medicine·2026

Same journal

Acute Right Ventricular Failure Triggered by Excessive Fluid Resuscitation in Septic Shock.

Case reports in medicine·2026

Same journal

Tourniquet-Induced Atypical Lower Back Pain Under Spinal Anesthesia: A Case Report and Mechanistic Exploration of Referred Pain.

Case reports in medicine·2026

Same journal

Paroxysmal Atrial Tachycardia With Atrioventricular Block: A Report of Two Cases.

Case reports in medicine·2026

Same journal

Incidental Tentorial Cerebelli Hypoplasia: A Case Report and Comprehensive Literature Review of Its Clinical and Imaging Characteristics.

Case reports in medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 15, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

Rapidly evolving giant dermatofibroma.

K J Lang¹, S Lidder, M Hofer

¹Department of General Surgery, Stoke Mandeville Hospital, Mandeville Road, Aylesbury, Bucks, HP21 8AL, UK.

Case Reports in Medicine

|March 13, 2010

Summary

This summary is machine-generated.

Giant dermatofibromas are rare benign skin tumors. This case highlights a rapidly growing giant dermatofibroma in the groin, emphasizing the importance of pathological diagnosis despite concerning initial presentation.

More Related Videos

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Related Experiment Videos

Last Updated: Jun 15, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Area of Science:

Dermatopathology
Oncology

Background:

Dermatofibroma, or fibrous histiocytoma, is a benign proliferation of fibroblasts and macrophages.
Typically presenting as a brownish nodule, it commonly affects the legs of females.
Giant dermatofibromas (>5 cm) are exceptionally rare, with limited documented cases.

Observation:

A case of a rapidly evolving, pedunculated mass in the groin of a male patient is presented.
Initial clinical and radiological features raised suspicion for malignancy.
Histological examination confirmed the lesion as a giant dermatofibroma.

Findings:

The presented case is a rare giant dermatofibroma, exceeding 5 cm in diameter.
Despite concerning initial presentation, pathological diagnosis confirmed a benign lesion.
Certain cellular subtypes may present as larger lesions with potential for recurrence.

Implications:

This case underscores the diagnostic challenge posed by giant dermatofibromas.
Accurate pathological diagnosis is crucial for differentiating benign lesions from malignant tumors.
Understanding the behavior of rare subtypes is important for patient management and prognosis.