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Updated: Jun 15, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
Published on: July 16, 2017
The graphical representation of protein sequences based on the physicochemical properties and its applications
Ping-An He1, Yan-Ping Zhang, Yu-Hua Yao
1Department of Mathematics, College of Science, Zhejiang Sci-Tech University, Hangzhou 310018, People's Republic of China. pinganhe@zstu.edu.cn
Abstract:
Based on the chaos game representation, a 2D graphical representation of protein sequences was introduced in which the 20 amino acids are rearranged in a cyclic order according to their physicochemical properties. The Euclidean distances between the corresponding amino acids from the 2-D graphical representations are computed to find matching (or conserved) fragments of amino acids between the two proteins. Again, the cumulative distance of the 2D-graphical representations is defined to compare the similarity of protein. And, the examination of the similarity among sequences of the ND5 proteins of nine species shows the utility of our approach.
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