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Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
08:20

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

Changing concepts in caries microbiology.

Roy R Russell1

  • 1Oral Biology, School of Dental Sciences, Newcastle University, Newcastle upon Tyne NE2 4BW, United Kingdom. r.r.russell@ncl.ac.uk

American Journal of Dentistry
|March 16, 2010
PubMed
Summary
This summary is machine-generated.

Understanding dental caries has evolved, with recent molecular techniques revealing the crucial roles of specific plaque bacteria and their virulence genes in tooth decay.

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Area of Science:

  • Microbiology
  • Molecular Biology
  • Dental Science

Background:

  • Theories on dental caries causes have evolved over centuries.
  • Microorganisms' role in caries recognized since the late 1800s.
  • Focus on identifying key bacterial species in dental caries.

Purpose of the Study:

  • To examine how technological advancements influence understanding of bacterial roles in dental caries.
  • To highlight the impact of molecular biology on caries research.
  • To explore genetic factors contributing to bacterial virulence in caries.

Main Methods:

  • Review of historical and contemporary research on dental caries etiology.
  • Analysis of technical advances in bacterial identification, cultivation, and enumeration.
  • Inclusion of molecular genetic studies on specific bacteria like Streptococcus mutans.

Main Results:

  • Molecular biological approaches have significantly reshaped views on bacterial contributions to caries.
  • Genetic studies provide insights into virulence mechanisms of key bacteria.
  • Improved identification and quantification methods enhance understanding of caries pathogenesis.

Conclusions:

  • Technological progress, especially in molecular biology, is critical for advancing dental caries research.
  • Understanding specific bacterial species and their genetic makeup is key to addressing caries.
  • Further research into bacterial virulence factors can inform novel prevention and treatment strategies.