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Preserving hesperetin nanosuspensions for dermal application
L Al Shaal1, R H Müller, C M Keck
1Department of Pharmaceutical Technology, Biopharmaceutics & NutriCosmetics, Freie Universität Berlin, Germany.
Die Pharmazie
|March 16, 2010
Summary
Preservatives can destabilize hesperidin nanosuspensions. Highly hydrophilic preservatives like Euxyl PE9010, Hydrolite-5, and Rokonsal PB5 maintained nanosuspension stability, unlike lipophilic ones.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Nanosuspensions require preservation for aqueous formulations.
- Preservatives can negatively impact nanosuspension physical stability.
Purpose of the Study:
- To evaluate the effect of six different preservatives on the physical stability of hesperetin nanosuspensions.
- To identify preservatives that maintain nanosuspension integrity.
Main Methods:
- Hesperetin nanosuspensions were prepared using Plantacare 2000 and high-pressure homogenization (HPH).
- Six preservatives (caprylyl glycol, Euxyl PE9010, Hydrolite-5, MultiEx naturotics, Phenonip, Rokonsal PB5) were added.
- Physical stability was assessed by measuring particle size (PCS) and zeta potential.
Main Results:
- Caprylyl glycol, MultiEx naturotics, and Phenonip caused significant aggregation (mean diameters 500-1070 nm).
- Euxyl PE9010, Hydrolite-5, and Rokonsal PB5 showed minimal impact on particle size (332-365 nm).
- Preservative lipophilicity correlated positively with destabilization effects.
Conclusions:
- Highly hydrophilic preservatives are recommended for maintaining hesperetin nanosuspension stability.
- Preservative selection is critical for the long-term physical integrity of nanosuspensions.
