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Mumps vaccine effectiveness in highly immunized populations

Angela Domínguez1, Núria Torner, Jesús Castilla

  • 1Department of Public Health, University of Barcelona, Casanova 143, 08036, Barcelona, Spain. angela.dominguez@ub.edu

Vaccine
|March 16, 2010
PubMed

Insights

This study found that the measles, mumps, and rubella (MMR) vaccine is highly effective against mumps, even in highly vaccinated populations. Achieving higher two-dose MMR coverage is crucial for preventing future mumps outbreaks.

Area of Science:

  • * Public Health
  • * Epidemiology
  • * Immunization

Background:

  • * Mumps outbreaks continue to occur in communities with high measles, mumps, and rubella (MMR) vaccine coverage.
  • * Understanding vaccine effectiveness (VE) is crucial for refining public health strategies.

Purpose of the Study:

  • * To investigate the effectiveness of the mumps component of the MMR vaccine during outbreaks in areas with high MMR coverage.
  • * To evaluate VE based on the number of MMR vaccine doses received.

Main Methods:

  • * Retrospective study of mumps cases reported to public health services in Navarre and Catalonia (2005-2007).
  • * Cases born between 1995 and 2005 were analyzed.
  • * Vaccine effectiveness was calculated using the screening method.

Main Results:

  • * Of 47 confirmed mumps cases, 85.1% had received at least one dose (1MMR) and 44.9% had received two doses (2MMR).
  • * Estimated VE for 1MMR was 85.4% (95% CI: 67.3-93.4).
  • * Estimated VE for 2MMR was 88.5% (95% CI: 78.1-93.9).

Conclusions:

  • * The MMR vaccine demonstrates high effectiveness against mumps, even in highly vaccinated populations.
  • * Increased two-dose MMR coverage is recommended to prevent future mumps outbreaks.
  • * Further research on VE using all confirmed cases and improved confirmation techniques is warranted.

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