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Infertility in Males

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

Infertility in Females

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...

Spermatogenesis

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...

Fertilization

Fertilization

During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...

Factors Affecting Drug Distribution: Physiological Barriers

Factors Affecting Drug Distribution: Physiological Barriers

Drug distribution in the body is intricately regulated by various physiological barriers that control the passage of substances. These include the capillary endothelial barrier, the blood-brain, blood-cerebrospinal fluid, blood-placental, and blood-testis barriers.
The capillary endothelial barrier allows only smaller molecules below 600 Da (Daltons) to pass through. It also restricts drugs like heparin that are bound to blood components, limiting their movement within the bloodstream.
The...

In Vitro Fertilization

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

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Related Experiment Video

Updated: Jun 15, 2026

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

Published on: October 24, 2025

Fertility and Sterility and impact factor.

Togas Tulandi, Fady F Shehata, Alan Decherney

Fertility and Sterility

|March 16, 2010

Summary

Journal impact factors are not solely increased by the number of publications. Article quality and a 5-year impact factor may offer a more stable journal evaluation metric.

Area of Science:

Bibliometrics
Scholarly Communication
Journal Evaluation

Background:

The study investigates the relationship between the quantity of published articles and journal impact factor (JIF).
It questions the direct correlation between increased publication volume and a higher JIF.
The influence of article type and quality on JIF is explored.

Discussion:

Findings suggest that simply increasing the number of articles or reviews does not guarantee a rise in JIF.
The quality and type of scholarly content are identified as potential key drivers of JIF.
A comparison is drawn between the traditional 2-year JIF and a 5-year JIF.

Key Insights:

Journal impact factor is not directly proportional to the number of published articles.

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Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

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Published on: September 16, 2021

Article quality and type significantly influence journal impact.

A 5-year impact factor demonstrates greater stability than the traditional 2-year metric.

Outlook:

The 5-year impact factor may serve as a more reliable indicator for journal performance evaluation.
Further research could explore the specific impact of different article types on JIF.
This analysis contributes to a nuanced understanding of bibliometric indicators in scholarly publishing.