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Related Experiment Video

Updated: Jun 15, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

[The default mode network: cognitive role and pathological disturbances].

K Mevel¹, B Grassiot, G Chételat

¹Inserm-EPHE, unité U923, laboratoire de neuropsychologie, GIP Cyceron, université de Caen -Basse-Normandie, and Department of neurology, CHU Côte de Nacre, 14033 Caen cedex, France.

Revue Neurologique

|March 16, 2010

Summary

The default mode network (DMN) is a set of brain regions active during rest, involved in self-related thought, memory, and attention. Its functions and changes in aging and diseases like Alzheimer's are increasingly understood.

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Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

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Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

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Last Updated: Jun 15, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

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Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

Published on: December 28, 2010

Area of Science:

Neuroscience
Cognitive Neuroscience
Functional Neuroimaging

Context:

The default mode network (DMN) comprises synchronized brain regions active during rest or task-independent states.
Recent research increasingly focuses on unraveling the cognitive functions of this intrinsic brain network.

Purpose:

To review anatomical, physiological, and phenomenological data on the DMN.
To explore proposed hypotheses regarding the DMN's role in cognition, including self-awareness, memory, and attention.
To discuss the DMN's alterations in normal aging, Alzheimer's disease (AD), and multiple sclerosis (MS).

Summary:

The DMN is implicated in autobiographical memory, prospection, self-referential thought, attention, and theory of mind.
Similarities between self-related brain activity and DMN regions (posterior cingulate, prefrontal areas) suggest introspective functions.
The DMN is a non-human-specific intrinsic network, active throughout life and sensitive to pathologies like AD and MS.

Impact:

Contributes to a refined understanding of the DMN's brain structures, mechanisms, and cognitive roles.
Highlights the DMN's potential involvement in both introspective processes and environmental monitoring.
Underscores the need for further research to clarify the DMN's precise functions and its modulation by consciousness levels and neurological conditions.