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Related Experiment Videos

Peripheral glucose metabolism in acromegaly.

M C Foss1, M J Saad, G M Paccola

  • 1Department of Medicine, School of Medicine of Ribeirao Preto, Sao Paulo University, Brazil.

The Journal of Clinical Endocrinology and Metabolism
|May 1, 1991
PubMed
Summary

Chronic growth hormone (GH) excess impairs muscle glucose uptake and nonoxidative metabolism in acromegaly. These metabolic derangements occur early, even in patients with normal glucose tolerance, indicating insulin resistance.

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Area of Science:

  • Endocrinology
  • Metabolic Research

Background:

  • Acromegaly is characterized by chronic excess of growth hormone (GH).
  • GH excess is associated with insulin resistance and altered glucose metabolism.

Purpose of the Study:

  • To investigate the impact of chronic GH excess on forearm muscle glucose uptake and oxidation.
  • To assess glucose metabolism in acromegalic patients during postabsorptive and post-glucose challenge states.

Main Methods:

  • Utilized forearm technique and indirect calorimetry to measure substrate exchange and oxidation.
  • Studied nine normal subjects and ten non-diabetic acromegalic patients.

Main Results:

  • Acromegalic patients exhibited significantly reduced forearm glucose uptake and nonoxidative glucose metabolism compared to normal subjects.

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  • Impaired glucose metabolism was observed even in acromegalic patients with normal glucose tolerance.
  • Muscle glucose oxidation rates and lipid metabolism did not differ significantly between groups.

    • Conclusions:

    • Chronic GH excess leads to impaired muscle glucose uptake and nonoxidative metabolism, contributing to insulin resistance in acromegaly.
    • These metabolic abnormalities are early derangements, present even before overt glucose intolerance develops.