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Plasma lipid transfer protein as a determinant of the atherogenicity of monkey plasma lipoproteins
E Quinet1, A Tall, R Ramakrishnan
1Department of Medicine, Columbia University College of Physicians and Surgeons, New York 10032.
The Journal of Clinical Investigation
|May 1, 1991
Summary
Cholesteryl ester transfer protein (CETP) levels, influenced by liver and adipose tissue, impact HDL and LDL cholesterol. Higher CETP concentrations correlate with increased atherosclerosis risk.
Area of Science:
- Biochemistry
- Cardiovascular Science
- Molecular Biology
Background:
- Cholesteryl ester transfer protein (CETP) plays a crucial role in lipoprotein metabolism.
- Understanding CETP's tissue sources and its influence on lipid profiles and atherosclerosis is vital for cardiovascular health research.
Purpose of the Study:
- To identify potential tissue sources of plasma CETP.
- To evaluate the impact of CETP on lipoprotein concentrations and the development of atherosclerosis.
Main Methods:
- Analysis of CETP mRNA abundance in liver and adipose tissue.
- Measurement of plasma CETP concentration and lipoprotein levels (HDL, LDL).
- Assessment of coronary artery atherosclerosis extent in cynomolgus monkeys fed atherogenic diets.
Main Results:
- Plasma CETP concentration strongly correlated with CETP mRNA in liver and adipose tissue.
- Higher CETP levels were inversely correlated with HDL cholesterol and positively correlated with LDL cholesterol and LDL particle size.
- Coronary artery atherosclerosis extent positively correlated with LDL cholesterol, LDL particle size, and plasma CETP concentration.
Conclusions:
- Individual variations in CETP mRNA in liver and adipose tissue significantly determine plasma CETP levels in monkeys on atherogenic diets.
- CETP influences cholesteryl ester distribution between LDL and HDL.
- Plasma CETP concentration is a key factor in determining lipoprotein atherogenicity.
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