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Related Experiment Video

Updated: Jun 15, 2026

A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures

A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures

Published on: July 2, 2014

Untangling memory from perception in the medial temporal lobe.

Wendy A Suzuki¹

¹Center for Neural Science, New York University, New York, NY 10003, USA. wendy@cns.nyu.edu

Trends in Cognitive Sciences

|March 16, 2010

Summary

The perirhinal cortex, crucial for learning and memory, has distinct functions from visual area TE. Evidence suggests its primary role is in declarative/relational memory, not high-level perception.

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Area of Science:

Neuroscience
Cognitive Science
Neurobiology

Background:

The perirhinal cortex (PRC), within the medial temporal lobe (MTL), is implicated in learning and memory.
A key debate questions if PRC's function is limited to declarative/relational memory or extends to high-level perception, like adjacent visual area TE.

Purpose of the Study:

To analyze neuroanatomical and neurophysiological evidence regarding the perirhinal cortex's function.
To argue for a distinct role of the PRC in declarative/relational learning and memory, separate from high-level perception.

Main Methods:

Review of existing neuroanatomical studies.
Analysis of neurophysiological research findings.
Comparative analysis of perirhinal cortex and visual area TE functions.

Main Results:

Neuroanatomical and neurophysiological data indicate the perirhinal cortex possesses unique structures and functions.
The perirhinal cortex's primary contribution is to declarative/relational learning and memory.
Its function is dissociable from that of the adjacent visual area TE.

Conclusions:

The perirhinal cortex is primarily involved in declarative/relational memory.
Its role is distinct from high-level visual perception.
Further neurophysiological studies are proposed to definitively differentiate between memory-specific and perception-inclusive roles.