Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

American Trypanosomiasis01:22

American Trypanosomiasis

Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
Toxoplasmosis01:28

Toxoplasmosis

Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activity-based proteomics uncovers suppressed hydrolases and a neo-functionalised antibacterial enzyme at the plant-pathogen interface.

The New phytologist·2023
Same author

Metallo-β-lactamase-mediated antimicrobial resistance and progress in inhibitor discovery.

Trends in microbiology·2023
Same author

Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine.

Journal of medicinal chemistry·2023
Same author

A human protein hydroxylase that accepts D-residues.

Communications chemistry·2023
Same author

The catalytic domains of all human KDM5 JmjC demethylases catalyse N-methyl arginine demethylation.

FEBS letters·2023
Same author

Dioxygen Binding Is Controlled by the Protein Environment in Non-heme Fe<sup>II</sup> and 2-Oxoglutarate Oxygenases: A Study on Histone Demethylase PHF8 and an Ethylene-Forming Enzyme.

Chemistry (Weinheim an der Bergstrasse, Germany)·2023

Related Experiment Video

Updated: Jun 15, 2026

Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates
13:55

Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates

Published on: January 27, 2019

Research needs for Chagas disease prevention.

Fernando Abad-Franch1, Walter S Santos, Christopher J Schofield

  • 1Instituto Leônidas e Maria Deane-Fiocruz Amazonia, Rua Teresina 476, 69057-070 Manaus, Amazonas, Brazil. fernando@amazonia.fiocruz.br

Acta Tropica
|March 16, 2010
PubMed
Summary

Effective Chagas disease (CD) prevention requires advances in both patient care and vector control. Research gaps in chemotherapy and triatomine vector ecology must be addressed for improved disease management.

More Related Videos

Demystifying In Vivo Bioluminescence Imaging of a Chagas Disease Mouse Model for Drug Efficacy Studies
07:59

Demystifying In Vivo Bioluminescence Imaging of a Chagas Disease Mouse Model for Drug Efficacy Studies

Published on: May 31, 2024

In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing &#946;-galactosidase
08:48

In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase

Published on: November 5, 2021

Related Experiment Videos

Last Updated: Jun 15, 2026

Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates
13:55

Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates

Published on: January 27, 2019

Demystifying In Vivo Bioluminescence Imaging of a Chagas Disease Mouse Model for Drug Efficacy Studies
07:59

Demystifying In Vivo Bioluminescence Imaging of a Chagas Disease Mouse Model for Drug Efficacy Studies

Published on: May 31, 2024

In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing &#946;-galactosidase
08:48

In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase

Published on: November 5, 2021

Area of Science:

  • Neglected Tropical Diseases
  • Parasitology
  • Vector-borne Diseases

Background:

  • Chagas disease (CD) prevention involves primary (vector control) and secondary (patient care) strategies.
  • Current approaches face challenges in chemotherapy and understanding disease pathogenesis.
  • Research on triatomine vectors often neglects direct disease control applications.

Purpose of the Study:

  • To provide an overview of Chagas disease prevention strategies.
  • To identify advances, knowledge gaps, and research needs in CD prevention.
  • To suggest improvements in vector control and patient care research.

Main Methods:

  • Literature review and analysis of research trends in Chagas disease.
  • Evaluation of current chemotherapy and vector control methodologies.
  • Assessment of triatomine systematics and its impact on control strategies.

Main Results:

  • Significant knowledge gaps exist in specific chemotherapy and understanding CD pathogenesis.
  • A small proportion of research on triatomine bugs focuses on direct disease control.
  • Current triatomine systematics may hinder effective vector ecology research and control.

Conclusions:

  • Sustained, problem-oriented research is crucial for advancing Chagas disease prevention.
  • Improvements in chemotherapy formulations and understanding host-parasite genetics are needed.
  • Enhanced research in vector ecology and systematics will support better control-surveillance schemes.