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Related Experiment Video

Updated: Jun 15, 2026

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition

Published on: February 1, 2012

Framing effect following bilateral amygdala lesion.

Deborah Talmi¹, René Hurlemann, Alexandra Patin

¹Wellcome Trust Centre for Neuroimaging, UCL, UK. deborah.talmi@manchester.ac.uk

Neuropsychologia

|March 16, 2010

Summary

Individuals with Urbach-Wiethe disease and amygdala damage still show the framing effect in decision-making. However, they gamble more, suggesting the amygdala influences risk-taking but not framing.

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Area of Science:

Neuroscience
Decision Science
Cognitive Psychology

Background:

The framing effect, a cognitive bias, demonstrates how choice presentation (gain vs. loss) influences decisions.
Previous fMRI studies linked amygdala activation to the framing effect.

Purpose of the Study:

To investigate the amygdala's role in the framing effect.
To examine decision-making patterns in patients with Urbach-Wiethe disease, characterized by amygdala degeneration.

Main Methods:

Studied two patients with Urbach-Wiethe disease and complete bilateral amygdala degeneration.
Assessed their decision-making behavior in scenarios involving potential gains and losses.
Compared their responses to control groups.

Main Results:

Patients with Urbach-Wiethe disease exhibited an intact framing effect, contrary to expectations.
However, their choice preferences showed a distinct pattern, with an increased propensity to gamble.
This suggests amygdala function influences overall risk-taking behavior.

Conclusions:

The amygdala may not play a causal role in the framing effect itself.
Alternatively, Urbach-Wiethe disease might not represent a pure lesion model for amygdala function in decision-making.
Amygdala integrity influences risk-taking, but its necessity for the framing effect is questionable.