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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Drug Release Characteristics01:22

Modified-Release Drug Delivery Systems: Drug Release Characteristics

Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Influencing Factors01:20

Modified-Release Drug Delivery Systems: Influencing Factors

Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
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Optimizing partition-controlled drug release from electrospun core-shell fibers.

Sandeep Kumar Tiwari1, Roey Tzezana, Eyal Zussman

  • 1School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore.

International Journal of Pharmaceutics
|March 16, 2010
PubMed
Summary

Controlled release of hydrophilic drugs is challenging. This study demonstrates electrospun core-shell fibers offer tunable drug release rates for peptides, proteins, and pDNA via partition control.

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Area of Science:

  • Biomaterials Engineering
  • Polymer Science
  • Drug Delivery Systems

Background:

  • Controlled release of hydrophilic molecules like peptides, proteins, and plasmid DNA (pDNA) presents significant challenges with traditional methods.
  • Developing effective delivery systems for these sensitive biomolecules is crucial for therapeutic advancements.

Purpose of the Study:

  • To investigate the use of electrospun core-shell fiber structures for the controlled release of hydrophilic entities.
  • To explore strategies for partition control in core-shell fibers to modulate release kinetics.
  • To demonstrate the feasibility of this approach for delivering drugs, peptides, and pDNA.

Main Methods:

  • Fabrication of core-shell nanofibers via electrospinning using various polymer combinations (PCL, PLLA, PLGA 80/20) for the shell and encapsulating a model hydrophilic drug (metoclopramide hydrochloride) in the core.
  • Systematic variation of the physical and chemical properties of the core and shell polymer solutions.
  • In vitro release studies to evaluate the release profiles of the encapsulated drug from different fiber configurations (monolithic vs. core-shell).

Main Results:

  • Core-shell fiber architecture allowed for tunable release rates of the hydrophilic drug, metoclopramide hydrochloride.
  • Significant differences in drug release patterns were observed between monolithic fibers and core-shell fibers with varying shell polymers (PCL, PLLA, PLGA 80/20).
  • Demonstrated that partition control, influenced by core-shell material properties, is achievable and effective in modulating release.

Conclusions:

  • Electrospun core-shell fibers provide a viable platform for achieving controlled release of hydrophilic actives.
  • The study offers valuable insights into the principles of partition control for designing advanced drug delivery systems.
  • This technology holds promise for the controlled delivery of challenging hydrophilic therapeutics, including peptides, proteins, and pDNA.