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Related Experiment Videos

Majocchi's granuloma.

K J Smith1, R C Neafie, H G Skelton

  • 1Department of Dermatopathology, AFIP, Washington, DC 30306-6000.

Journal of Cutaneous Pathology
|February 1, 1991
PubMed
Summary

Majocchi's granuloma is an uncommon fungal infection. Morphologic variations in dermatophytes may allow them to persist in deeper skin layers, potentially occurring in two patient groups.

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Area of Science:

  • Dermatology
  • Mycology
  • Infectious Diseases

Background:

  • Majocchi's granuloma (nodular granulomatous perifolliculitis) is a rare fungal infection affecting the dermis and subcutaneous tissue.
  • Typically caused by dermatophytes, it usually remains confined to the superficial epidermis.
  • Trichophyton rubrum is the most common etiological agent, but other dermatophytes can also be involved.

Purpose of the Study:

  • To review the variety of fungal organisms causing Majocchi's granuloma.
  • To investigate unusual morphologic forms of dermatophytes in this condition.
  • To explore potential patient groupings for Majocchi's granuloma.

Main Methods:

  • Review of 17 cases of Majocchi's granuloma.
  • Analysis of causative fungal organisms.
  • Examination of fungal morphology in affected tissues.

Main Results:

  • Identified a variety of dermatophyte species responsible for Majocchi's granuloma.
  • Observed significant morphologic variations, including yeast forms and bizarre hyphae.
  • Noted the presence of the Splendore-Hoeppeli phenomenon in some cases.
  • Found evidence suggesting two distinct patient groups associated with the condition.

Conclusions:

  • Majocchi's granuloma involves a broader range of dermatophytes than previously recognized.
  • Unusual fungal morphologic variations may contribute to the infection's persistence in deeper tissues.
  • Further research is warranted to understand the two distinct patient groups identified.

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