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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

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Related Experiment Video

Updated: Jun 15, 2026

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
14:02

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Published on: November 1, 2012

Magnesium homeostasis and aging.

Mario Barbagallo1, Mario Belvedere, Ligia J Dominguez

  • 1Geriatric Unit, Department of Internal Medicine and Emergent Pathologies, University of Palermo, Italy. mabar@unipa.it

Magnesium Research
|March 16, 2010
PubMed
Summary

Aging often leads to magnesium (Mg) deficits, increasing the risk of age-related diseases. Addressing Mg deficiency may mitigate inflammation and oxidative stress linked to aging.

Area of Science:

  • Gerontology and Nutritional Science
  • Biochemistry and Molecular Biology

Background:

  • Aging is frequently linked to a decline in total body and intracellular magnesium (Mg) levels.
  • Dietary Mg deficiencies, reduced intestinal absorption, and increased urinary loss contribute to Mg deficits in the elderly.
  • Conditions like insulin resistance and certain medications can exacerbate Mg deficits in older adults.

Purpose of the Study:

  • To explore the association between aging, magnesium deficit, and age-related diseases.
  • To investigate the role of magnesium in inflammation and oxidative stress during the aging process.

Main Methods:

  • Review of existing literature on magnesium status in aging populations.
  • Analysis of the link between chronic Mg deficits and various preclinical and clinical outcomes.

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Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
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Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans

Published on: February 16, 2017

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Last Updated: Jun 15, 2026

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
14:02

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Published on: November 1, 2012

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
10:10

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans

Published on: February 16, 2017

  • Examination of the interplay between Mg, inflammation, and oxidative stress in aging.

    • Main Results:

    • Total body and intracellular Mg decrease with age, with dietary deficiencies being common in the elderly.
    • Chronic Mg deficits are associated with increased risks of hypertension, diabetes, cardiovascular diseases, inflammation, and oxidative stress.
    • Both aging and Mg deficiency contribute to increased free radical production and low-grade inflammation.

    Conclusions:

    • Magnesium deficit is a significant factor in aging, potentially linking inflammation and oxidative stress to age-related conditions.
    • Maintaining adequate magnesium levels may be crucial for mitigating age-associated health risks.
    • Further research into Mg's role in age-related pathophysiology is warranted.