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Updated: Jun 15, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Formulation and evaluation of multiple tablets as a biphasic gastroretentive floating drug delivery system for
Suresh Bandari1, Chandra Mohan Eaga, Ashok Thadishetty
1Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009 (A.P.), India.
Abstract:
A biphasic gastroretentive drug delivery system of fenoverine was developed to maintain constant plasma concentration. The delivery system consisted of a loading-dose tablet and a floating multiple matrix tablet prepared by the direct compression process. The drug release from biphasic GRDDS in 0.1 mol L(-1) HCl and SGF (enzyme free) was sustained over 12 h with buoyant properties. Stability studies showed no significant change in dissolution profiles (f2 value > 50). Based on the release kinetics, it can be concluded that the floating multiple matrix tablet containing HPMC was a particularly suitable gastroretentive drug delivery system with a zero-order release profile.
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