Intermediate sized CGG repeats are not a common cause of idiopathic premature ovarian failure
Claire E Bennett1, Gerard S Conway, James N Macpherson
1Peninsula Medical School, University of Exeter, Exeter EX1 2LU, UK.
Background:
It is recognized that FMR1 premutation expansions are associated with premature ovarian failure (POF), but the role of smaller repeats at the boundary of premutation and normal is less clear.
Methods:
We have therefore investigated the incidence of these intermediate sized FMR1 CGG repeats (35-58 repeats) in a series of 366 women ascertained because of menopause before the age of 40.
Results:
We found no significant difference in the incidence of intermediates in cases compared with controls. Thus, we were unable to replicate previous studies showing a positive association, despite a significantly larger sample size.
Conclusions:
We therefore conclude that intermediate sized FMR1 CGG repeat alleles should not be considered a high-risk factor for POF based on current evidence.
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