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Related Concept Videos

Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
Microbiota of the Stomach and Small Intestine01:27

Microbiota of the Stomach and Small Intestine

The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
Peptic Ulcer01:27

Peptic Ulcer

Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the mucus...
Peptic Ulcer Disease II: Pathophysiology01:24

Peptic Ulcer Disease II: Pathophysiology

Peptic ulcer disease develops when protective mechanisms of the gastrointestinal mucosa are overwhelmed by harmful factors, leading to localized erosions in the stomach or proximal duodenum. The main causes are Helicobacter pylori infection and chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs).Helicobacter pylori–Induced InjuryBacterial Adaptation and Colonization:H. pylori is a spiral, Gram-negative bacterium adapted to the acidic stomach. and transmitted through oral-oral or...
Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.

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Related Experiment Video

Updated: Jun 15, 2026

High Resolution Electron Microscopy of the Helicobacter pylori Cag Type IV Secretion System Pili Produced in Varying Conditions of Iron Availability
09:05

High Resolution Electron Microscopy of the Helicobacter pylori Cag Type IV Secretion System Pili Produced in Varying Conditions of Iron Availability

Published on: November 21, 2014

Helicobacter pylori and micronutrients.

Mustafa Akcam1

  • 1Department of Pediatrics, Division of Pediatric Gastroenterology Hepatology and Nutrition, Medical School, Suleyman Demirel University, Turkey. makcam@sdu.edu.tr

Indian Pediatrics
|March 16, 2010
PubMed
Summary

Helicobacter pylori (HP) infection negatively impacts iron, vitamin B12, and vitamin C levels, particularly in children. Further research is needed to clarify HP

Area of Science:

  • Microbiology
  • Nutritional Science
  • Public Health

Background:

  • Helicobacter pylori (HP) infection is a global health concern, prevalent in developing nations.
  • HP infection is linked to gastrointestinal morbidity and is inversely associated with socioeconomic status.
  • The interplay between HP infection, nutrition, and growth failure, especially in children, requires further investigation.

Purpose of the Study:

  • To review the relationship between Helicobacter pylori infection and micronutrient status.
  • To explore the impact of HP infection on nutritional status, particularly in childhood.
  • To examine the potential influence of nutritional status on HP infection.

Main Methods:

  • Comprehensive literature search of PubMed publications from 1990-2009.

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One-step Negative Chromatographic Purification of Helicobacter pylori Neutrophil-activating Protein Overexpressed in Escherichia coli in Batch Mode
10:44

One-step Negative Chromatographic Purification of Helicobacter pylori Neutrophil-activating Protein Overexpressed in Escherichia coli in Batch Mode

Published on: June 18, 2016

Related Experiment Videos

Last Updated: Jun 15, 2026

High Resolution Electron Microscopy of the Helicobacter pylori Cag Type IV Secretion System Pili Produced in Varying Conditions of Iron Availability
09:05

High Resolution Electron Microscopy of the Helicobacter pylori Cag Type IV Secretion System Pili Produced in Varying Conditions of Iron Availability

Published on: November 21, 2014

One-step Negative Chromatographic Purification of Helicobacter pylori Neutrophil-activating Protein Overexpressed in Escherichia coli in Batch Mode
10:44

One-step Negative Chromatographic Purification of Helicobacter pylori Neutrophil-activating Protein Overexpressed in Escherichia coli in Batch Mode

Published on: June 18, 2016

  • Focus on studies concerning HP infection and micronutrients (iron, vitamins B12, C, A, E, folate, selenium) in children.
  • Inclusion of relevant adult and experimental studies.

    • Main Results:

    • HP infection demonstrates a negative effect on iron, vitamin B12, and vitamin C metabolism.
    • Evidence suggests HP infection impacts the bioavailability and metabolism of key micronutrients.
    • The influence of HP infection on other micronutrients like vitamin A, E, folate, and selenium remains unclear.

    Conclusions:

    • Helicobacter pylori infection significantly affects the metabolism of essential micronutrients, including iron and certain vitamins.
    • The findings highlight the nutritional burden of HP infection, especially in vulnerable populations.
    • Further research is warranted to elucidate the mechanisms and extent of HP's impact on various micronutrients.