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Association of low ankle-brachial index with mortality in patients with ischemic heart disease

Liqiang Zheng1, Jue Li, Dayi Hu

  • 1Department of Cardiology, Shengjing Hospital of China Medical University, 155 Nanjing North Street, Heping, Shenyang, China. liqiangzhang@126.com

Journal of Atherosclerosis and Thrombosis
|March 16, 2010
PubMed

Insights

A low ankle-brachial index (ABI) significantly predicts increased all-cause and cardiovascular mortality in ischemic heart disease patients. Adding ABI to risk models improves 3-year mortality prediction, supporting its use in prognostic assessments.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Public Health

Background:

  • The ankle-brachial index (ABI) is a key indicator of peripheral artery disease.
  • Its role in predicting mortality in ischemic heart disease (IHD) patients requires further clarification.
  • Conventional risk factors may not fully capture mortality risk in IHD.

Purpose of the Study:

  • To assess the association between ABI and all-cause and cardiovascular mortality in Chinese IHD patients.
  • To determine if ABI improves mortality prediction beyond established risk factors.
  • To evaluate the prognostic value of ABI in IHD.

Main Methods:

  • An observational prospective study involving 1,800 Chinese patients (age ≥35 years).
  • Follow-up duration from 2004 to 2007-2008.
  • Analysis of mortality rates across different ABI categories.

Main Results:

  • A significant inverse association was observed between ABI and mortality.
  • Lower ABI categories showed progressively higher hazard ratios for all-cause and cardiovascular mortality.
  • The ABI significantly enhanced the predictive value of mortality models (p<0.001).

Conclusions:

  • The ankle-brachial index is a strong independent predictor of mortality in IHD patients.
  • Incorporating ABI into risk assessment significantly improves 3-year mortality prediction.
  • Routine measurement of ABI is recommended for prognostic evaluation in IHD.
Abstract

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