Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
The Inner Mitochondrial Membrane01:28

The Inner Mitochondrial Membrane

The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A minimally invasive, scalable and reproducible neonatal rat model of severe focal brain injury.

Brain communications·2026
Same author

ODin (Orthology Data driven Interaction) Predictor: A Client‑Side Web Application for Unveiling Biological Connections Through Orthology from Alliance of Genome Resources.

microPublication biology·2026
Same author

Chronic intestinal immune activation reveals separable impacts of inflammation and barrier loss on hallmarks of ageing.

PloS one·2026
Same author

Altered cerebral thyroid hormone, WNT and NOTCH signalling and impaired myelination following intrauterine growth restriction in rats.

Neuroscience·2026
Same author

Parkin overexpression modulates gut-microbiota composition during aging in <i>Drosophila melanogaster</i>.

Frontiers in microbiology·2025
Same author

Spatiotemporal Characterisation of Key Cortical Developmental Markers in the Developing Ferret Brain.

Developmental neuroscience·2025
Same journal

Short-term responsiveness of DNA methylation-based aging biomarkers to a multimodal intervention comprising exercise and dietary guidance involving daily consumption of yogurt containing <i>Bifidobacterium longum</i> BB536: an exploratory randomized controlled trial.

Aging·2026
Same journal

Hormonal dimorphism in sarcopenia disease.

Aging·2026
Same journal

The multifaceted inducers of cellular senescence.

Aging·2026
Same journal

Life expectancy and causes of death in classical laminopathic progeroid syndromes: systematic review with individual-patient data synthesis.

Aging·2026
Same journal

Age-related dysfunctions of the neuroendocrine axes in nonhuman primates with depression-like and anxious behavior.

Aging·2026
Same journal

The love and hate relationship between cellular senescence and stemness.

Aging·2026
See all related articles

Related Experiment Video

Updated: Jun 15, 2026

Imaging and Quantifying Mitochondrial Morphology in C. elegans During Aging
05:29

Imaging and Quantifying Mitochondrial Morphology in C. elegans During Aging

Published on: January 17, 2025

Aging: Dial M for Mitochondria.

Jae H Hur1, Jaehyoung Cho, David W Walker

  • 1Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Aging
|March 16, 2010
PubMed
Summary
This summary is machine-generated.

Moderate inactivation of mitochondrial electron transport chain (ETC) genes can extend lifespan. This study investigated ETC components

Keywords:
C. elegansDrosophilalongevityrespiratory chain

More Related Videos

Quantitative Analysis of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Stabilization in a Neural Model of Alzheimer's Disease (AD)
06:41

Quantitative Analysis of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Stabilization in a Neural Model of Alzheimer's Disease (AD)

Published on: January 10, 2025

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase (COX/SDH) Double-labeling Histochemistry
06:53

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase (COX/SDH) Double-labeling Histochemistry

Published on: November 23, 2011

Related Experiment Videos

Last Updated: Jun 15, 2026

Imaging and Quantifying Mitochondrial Morphology in C. elegans During Aging
05:29

Imaging and Quantifying Mitochondrial Morphology in C. elegans During Aging

Published on: January 17, 2025

Quantitative Analysis of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Stabilization in a Neural Model of Alzheimer's Disease (AD)
06:41

Quantitative Analysis of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Stabilization in a Neural Model of Alzheimer's Disease (AD)

Published on: January 10, 2025

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase (COX/SDH) Double-labeling Histochemistry
06:53

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase (COX/SDH) Double-labeling Histochemistry

Published on: November 23, 2011

Area of Science:

  • Aging research
  • Genetics
  • Molecular biology

Background:

  • Genetic studies in nematodes and rodents suggest that modifying mitochondrial electron transport chain (ETC) function can influence lifespan.
  • Identifying conserved mechanisms of aging across species is crucial for understanding longevity.

Purpose of the Study:

  • To investigate the role of mitochondrial electron transport chain (ETC) components in modulating lifespan in Drosophila melanogaster.
  • To explore the potential conserved mechanisms of aging related to ETC function between flies, worms, and mice.

Main Methods:

  • Conducted a large-scale RNA interference (RNAi) screen targeting genes involved in the mitochondrial electron transport chain (ETC).
  • Utilized Drosophila melanogaster (fruit fly) as a model organism to assess lifespan changes.
  • Analyzed the impact of specific ETC gene inactivations on organismal longevity.

Main Results:

  • Identified specific mitochondrial electron transport chain (ETC) components whose moderate inactivation affects lifespan in fruit flies.
  • Findings suggest a conserved role for ETC function in lifespan regulation across different species.

Conclusions:

  • The study provides evidence that modulating mitochondrial ETC function is a potential conserved mechanism for lifespan extension.
  • Results warrant further investigation into the specific ETC pathways and their therapeutic potential in aging research.