Related Experiment Video
Updated: Jun 15, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Disseminated plasmacytoma of the thyroid
Brian J Park1, Randy J Kalish, Arthur P Vercillo
1Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.
Abstract:
Extramedullary plasmacytomas most commonly occur in the nasal cavity, nasopharynx, paranasal sinuses, and larynx. Thyroid involvement is rare, as fewer than 75 cases have been previously reported in the literature. We report a new case of disseminated plasmacytoma of the thyroid, which occurred in a 68-year-old woman. The diagnosis was made with an incisional biopsy. The patient initially experienced a complete response to radiotherapy (46.8 Gy in 26 fractions), but she developed multiple metastases at distant sites, including the breast, abdominal wall, and buttock despite various chemotherapy regimens. Ultimately, she was placed on palliative radiotherapy. We also briefly review the diagnostic and treatment options for patients with extramedullary plasmacytoma.
Related Concept Videos
Graves Disease II: Pathophysiology
Hyperthyroidism II: Pathophysiology
The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Graves' Disease I: Introduction
Hyperthyroidism I: Introduction
Goiter

