Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Motor Unit Stimulation01:20

Motor Unit Stimulation

When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...
Muscle Stimulation Frequency01:22

Muscle Stimulation Frequency

The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Fatigue01:21

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparing effects of gaseous vs. particulate components of traffic-related air pollution on Alzheimer's disease biomarkers in a genetically susceptible rat model.

Neurotoxicology·2026
Same author

Cartilage thickness at the apex of femoral resections in kinematically aligned total knee arthroplasty is close to 2.5 millimeters.

Journal of experimental orthopaedics·2026
Same author

A fixed 2 mm adjustment for worn distal femoral cartilage when the cartilage of the unworn compartment is ≥3 mm does not negatively affect outcome scores after kinematically aligned total knee arthroplasty.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2026
Same author

One third of patients have articular cartilage thickness greater than three millimeters measured from femoral resections in kinematically aligned total knee arthroplasty.

The Knee·2026
Same author

Spatial and spectral mapping of traffic-related nanoparticles in hippocampal subregions of an Alzheimer disease model.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Switching From a 6° to a 20° Valgus Prosthetic Trochlear Groove Improved the Forgotten Joint and Oxford Knee Scores After Kinematically Aligned Total Knee Arthroplasty.

Arthroplasty today·2026

Related Experiment Video

Updated: Jun 15, 2026

Determining The Electromyographic Fatigue Threshold Following a Single Visit Exercise Test
06:00

Determining The Electromyographic Fatigue Threshold Following a Single Visit Exercise Test

Published on: July 27, 2015

Predicting fatigue during electrically stimulated non-isometric contractions.

M Susan Marion1, Anthony S Wexler, Maury L Hull

  • 1Biomedical Engineering Program, Bainer Hall, University of California, One Shields Avenue, Davis, California 95616, USA. msmarion@ucdavis.edu

Muscle & Nerve
|March 16, 2010
PubMed
Summary

A new mathematical model predicts power loss during electrically stimulated muscle contractions, aiding in fatigue management and understanding force-velocity relationships in functional electrical stimulation systems.

More Related Videos

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
14:02

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Published on: November 1, 2012

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

Related Experiment Videos

Last Updated: Jun 15, 2026

Determining The Electromyographic Fatigue Threshold Following a Single Visit Exercise Test
06:00

Determining The Electromyographic Fatigue Threshold Following a Single Visit Exercise Test

Published on: July 27, 2015

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
14:02

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Published on: November 1, 2012

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

Area of Science:

  • Biomechanics
  • Physiology
  • Mathematical Modeling

Background:

  • Minimizing power loss during electrically stimulated contractions is crucial for managing fatigue and understanding muscle function.
  • Existing models often focus on isometric contractions or lack integration with non-isometric force dynamics.

Purpose of the Study:

  • To develop a novel mathematical model for predicting non-isometric fatigue during electrically stimulated, open-chain leg extensions.
  • To experimentally validate the predictive capabilities of the developed force-fatigue model.

Main Methods:

  • A computer-controlled stimulator delivered electrical pulses to thigh surface electrodes in 17 able-bodied subjects.
  • Measurements included isometric and non-isometric torque and knee angle during non-fatiguing and fatiguing leg extensions.
  • A new non-isometric force-fatigue model was created by combining existing force and fatigue models, incorporating angular velocity and three new parameters derived from the force model.

Main Results:

  • The developed force-fatigue model explained over 60% of the variability in measured leg extension torque and angle.
  • The model successfully integrated non-isometric force dynamics with fatigue progression without requiring additional subject measurements.
  • Validation confirmed the model's ability to predict power loss during electrically stimulated contractions.

Conclusions:

  • The new mathematical model provides a valuable tool for investigating the mechanisms of non-isometric muscle fatigue.
  • This model can enhance the design and performance optimization of functional electrical stimulation (FES) systems.
  • It offers insights for both clinical applications aimed at minimizing fatigue and research exploring force-velocity contributions.