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Related Concept Videos

Models of Health Promotion and Illness Prevention II01:18

Models of Health Promotion and Illness Prevention II

The person's health status fluctuates continually, varying from being in good health to becoming ill and returning to being healthy. To understand the concept of illness prevention, there are two models. First, the health-illness continuum model is a graphic representation of an individual's wellness. It states that a person is considered healthy in the absence of physical disease and the presence of good emotional health.
The agent-host-environment model states that disease results from...
Clearance Models: Physiological Models01:09

Clearance Models: Physiological Models

Drug clearance is a critical pharmacokinetic process involving the irreversible removal of drugs from the body through various organs over a specified time period. Physiological models are indispensable in determining organ-specific clearance, defined by the proportion of the drug eliminated per unit of time from the organ's blood volume.
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's proficiency in drug...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
Models of Health Promotion and Illness Prevention I01:25

Models of Health Promotion and Illness Prevention I

A model is a theoretical way to understand a concept or an idea. Models can overcome barriers to health regardless of diverse economic and cultural backgrounds. In addition, models make the task easier by providing different ways to approach complex issues. There are two major health promotion models: the health belief model and the health promotion model.
The health belief model (HBM) attempts to predict health-related behavior in specific belief patterns. According to the HBM, a person's...

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Related Experiment Video

Updated: Jun 15, 2026

A Rat Model of EcoHIV Brain Infection
08:48

A Rat Model of EcoHIV Brain Infection

Published on: January 21, 2021

[Animal AIDS models].

Hiroshi Ishii1, Tetsuro Matano

  • 1International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|March 17, 2010
PubMed
Summary
This summary is machine-generated.

Understanding human immunodeficiency virus (HIV) progression to AIDS requires studying animal models like simian immunodeficiency virus (SIV) in macaques. Research on HIV, SIV, and chimeric viruses aids in understanding viral replication and tropism mechanisms.

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Last Updated: Jun 15, 2026

A Rat Model of EcoHIV Brain Infection
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Published on: January 21, 2021

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
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Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

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Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
07:10

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Published on: January 7, 2019

Area of Science:

  • Virology
  • Immunology
  • Pathogenesis

Context:

  • Human immunodeficiency virus (HIV) infection leads to Acquired Immunodeficiency Syndrome (AIDS) due to the failure of host immune responses to control viral replication.
  • Studying HIV-infected individuals and animal models is crucial for understanding in vivo viral replication and disease progression.
  • Simian immunodeficiency virus (SIV) infection in macaques serves as the primary animal model for human AIDS research.

Purpose:

  • To investigate the mechanisms underlying persistent HIV infection and AIDS progression.
  • To analyze viral replication in vivo using both human and animal models.
  • To elucidate the determinants of viral tropism through comparative studies of HIV, SIV, and chimeric viruses.

Summary:

  • Host immune responses are insufficient to control HIV replication, leading to AIDS.
  • Animal models, particularly SIV in macaques, are vital for studying AIDS pathogenesis.
  • Comparative analysis of HIV, SIV, and chimeric viruses in humans and macaques can reveal mechanisms of viral tropism.

Impact:

  • Enhanced understanding of HIV pathogenesis and AIDS progression.
  • Improved strategies for studying viral replication and host-pathogen interactions.
  • Potential insights into controlling viral tropism and developing novel therapeutic interventions.