Related Experiment Video

Updated: Jun 15, 2026

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
19:57

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

[Treatment strategy for HIV/AIDS including guidelines]

Atsushi Ajisawa1

  • 1Department of Infectious Diseases, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|March 17, 2010
PubMed

Insights

Highly active antiretroviral therapy (HAART) significantly improves HIV outcomes but can lead to metabolic syndrome, kidney disease, and malignancies. Optimizing HAART initiation and selection may prevent long-term complications.

Area of Science:

  • Infectious Diseases
  • Immunology
  • Endocrinology

Context:

  • Highly active antiretroviral therapy (HAART) has transformed HIV management, reducing mortality.
  • Long-term HAART use is associated with metabolic complications, including dyslipidemia and fat redistribution.
  • Increased incidence of chronic kidney disease (CKD) and non-AIDS malignancies are reported in HIV patients on HAART.

Purpose:

  • To investigate the long-term complications associated with highly active antiretroviral therapy (HAART) in HIV patients.
  • To understand the relationship between HAART regimens and the development of metabolic syndrome, CKD, and malignancies.
  • To determine optimal HAART strategies for preserving immune function and preventing treatment-related comorbidities.

Summary:

  • HAART has drastically decreased HIV-related illness and death.
  • However, metabolic syndrome (dyslipidemia, fat redistribution), CKD, and non-AIDS malignancies are common in patients on HAART.
  • The timing and choice of HAART are critical for immune preservation and mitigating long-term adverse effects.

Impact:

  • Optimizing HAART initiation and drug selection can improve long-term health outcomes for HIV patients.
  • Understanding these risks allows for proactive monitoring and management of potential complications.
  • This research informs clinical practice guidelines for HIV treatment and patient care.

More Related Videos

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors05:46

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice06:07

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

Related Concept Videos

Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Antiviral Nucleoside Inhibitors01:22

Antiviral Nucleoside Inhibitors

Antiviral Nucleoside InhibitorsAntiviral nucleoside inhibitors are structural analogs of natural nucleosides that interfere with viral DNA or RNA synthesis. These compounds selectively target viral polymerases due to their resemblance to host nucleosides, thereby disrupting viral genome replication.Mechanism of Acyclovir ActionAcyclovir is a guanosine analog with a three-carbon acyclic side chain. It selectively targets herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2),...
Treatment Strategies for Psychological Disorders01:24

Treatment Strategies for Psychological Disorders

Treatment approaches for psychological disorders fall into three main categories: psychological, biological, and sociocultural. Each approach targets different aspects of mental health, requiring varying levels of education and training.
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...