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Updated: Jun 15, 2026

A Neurite Outgrowth Assay and Neurotoxicity Assessment with Human Neural Progenitor Cell-Derived Neurons

A Neurite Outgrowth Assay and Neurotoxicity Assessment with Human Neural Progenitor Cell-Derived Neurons

Published on: August 6, 2020

[NeuroAIDS].

Masanori Nakagawa¹, Masaki Kondo

¹Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|March 17, 2010

Summary

Highly active antiretroviral therapy (HAART) reduced NeuroAIDS, but increased other neurological issues. HIV patients need monitoring for neurological complications, even without symptoms, as cerebral blood flow may decrease.

Area of Science:

Neuroscience
Infectious Diseases
Neurology

Context:

Highly active antiretroviral therapy (HAART) has decreased AIDS dementia (NeuroAIDS) incidence in HIV patients.
However, HAART is associated with increased immune reconstitution inflammatory syndrome, opportunistic infections, peripheral neuropathy, and cerebrovascular disorders.
Neural injury and milder cognitive and motor disorder (MCMD) persist in some HIV patients despite HAART, with longer infection duration and older age at seroconversion increasing risk.

Purpose:

To review recent advances in NeuroAIDS research.
To highlight the continued risk of neurological complications in HIV patients.
To emphasize the need for monitoring cerebral blood flow and neurological status in HIV patients.

Summary:

This review discusses the evolving landscape of neurological complications in HIV infection post-HAART.

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It highlights the reduced incidence of NeuroAIDS but increased prevalence of other neurological issues.

The study found reduced cerebral blood flow in asymptomatic HIV patients, suggesting subclinical neural injury.

Impact:

Underscores the importance of vigilant monitoring for NeuroAIDS and other neurological disorders in HIV patients.
Advocates for collaborative care involving neurologists, immunologists, and clinical psychologists.
Suggests the need for advanced neuroimaging techniques like SPECT to detect early signs of neurological compromise.