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Microbiome of the Eye

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...

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Microbial keratitis after LASIK.

Prashant Garg¹, Sunita Chaurasia, Pravin K Vaddavalli

¹Cornea and Anterior Segment Service and Jhaveri Microbiology Center, L V Prasad Eyes Institute, Hyperabad, India. prashant@lvpei.org

Journal of Refractive Surgery (Thorofare, N.J. : 1995)

|March 17, 2010

Summary

This summary is machine-generated.

Microbial keratitis after LASIK in tropical zones can be caused by unusual organisms like fungi and Nocardia. Prompt microbiology evaluation is crucial for accurate diagnosis and effective treatment of LASIK infections.

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Area of Science:

Ophthalmology
Microbiology
Infectious Diseases

Background:

Laser-assisted in situ keratomileusis (LASIK) is a common refractive surgery.
Post-LASIK microbial keratitis poses a significant risk to visual acuity.
Tropical climates may harbor unique microbial pathogens that can cause ocular infections.

Purpose of the Study:

To document cases of microbial keratitis following LASIK surgery in a tropical region.
To identify the spectrum of microorganisms responsible for post-LASIK keratitis in this setting.
To evaluate treatment outcomes for microbial keratitis after LASIK.

Main Methods:

A retrospective case series of 17 eyes from 15 patients with post-LASIK keratitis.
Detailed clinical evaluation and corneal scrapings for microbiological analysis.
Treatment included antimicrobial irrigation, flap amputation, tissue adhesive, and penetrating keratoplasty (PK) based on clinical presentation and microbiology.

Main Results:

Commonly isolated microorganisms included filamentous fungi, Nocardia asteroides, atypical mycobacteria, and Acanthamoeba.
Treatment success varied, with resolution achieved through medical management, flap amputation, or PK.
Early intervention within 10 days of symptom onset showed favorable visual outcomes with medical treatment.

Conclusions:

In tropical climates, post-LASIK keratitis may be caused by atypical pathogens.
Comprehensive microbiological investigation is essential for diagnosing and managing post-LASIK keratitis.
Timely and appropriate treatment, guided by microbiology, improves visual outcomes.