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Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...

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Related Experiment Video

Updated: Jun 15, 2026

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

Techniques for efficient entrapment of pharmaceuticals in biodegradable solid micro/nanoparticles.

Tsutomu Ishihara¹, Tohru Mizushima

¹Kumamoto University, Graduate School of Medical and Pharmaceutical Sciences, Oe-honmachi, Kumamoto, Japan. tishihar@kumamoto-u.ac.jp

Expert Opinion on Drug Delivery

|March 17, 2010

Summary

Developing biodegradable solid particles for drug delivery is challenging. Achieving stable drug encapsulation and controlled release depends on complex factors and various techniques, influencing pharmaceutical activity.

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Last Updated: Jun 15, 2026

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

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Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

Area of Science:

Pharmaceutical Sciences
Materials Science

Background:

Biodegradable solid particles serve as drug carriers for both hydrophobic and hydrophilic compounds.
Marketed applications focus on prolonging pharmaceutical activity.

Purpose of the Study:

Review principles and techniques for preparing biodegradable drug-carrying particles.
Highlight challenges in achieving stable encapsulation and controlled release.

Main Methods:

Review of existing literature on particle preparation techniques.
Analysis of factors influencing drug encapsulation and release.

Main Results:

Effective drug entrapment and controlled release are complex and multifactorial.
Encapsulation efficiency can be enhanced via hydrophobic interaction, covalent bonding, ionic interaction, and physical isolation.
Drug release is significantly affected by environmental conditions and polymer-drug physicochemical properties.

Conclusions:

Solid particles with targeting capabilities and prolonged biological activity show promise for novel pharmaceutical development.
Further research is needed to overcome challenges in achieving predictable drug delivery profiles.