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Regulation of Angiogenesis and Blood Supply

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Updated: Jun 15, 2026

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
06:55

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

Angiogenic imbalances: the obstetric perspective.

Jimmy Espinoza1, John E Uckele, Robert A Starr

  • 1Department of Obstetrics and Gynecology, William Beaumont Hospital, 3601 West Thirteen Mile Rd., Royal Oak, MI 48073, USA. jimmy.espinoza@beaumont.edu

American Journal of Obstetrics and Gynecology
|March 17, 2010
PubMed
Summary
This summary is machine-generated.

Angiogenic imbalances are implicated in dangerous pregnancy complications. Targeting these imbalances, potentially involving the fetus, may offer new treatments.

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Last Updated: Jun 15, 2026

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Area of Science:

  • Obstetrics and Gynecology
  • Vascular Biology
  • Perinatal Medicine

Background:

  • Angiogenic imbalances are increasingly recognized as key factors in the pathophysiology of various pregnancy complications.
  • Several pregnancy complications, including preeclampsia and fetal growth restriction, are associated with dysregulated angiogenesis.
  • The fetus itself may significantly contribute to these angiogenic imbalances.

Purpose of the Study:

  • To review current clinical and experimental evidence linking angiogenic imbalances to pregnancy complications.
  • To explore the potential central role of the fetus in these angiogenic disturbances.
  • To summarize recent findings on the prophylactic and therapeutic potential of modulating angiogenic imbalances during pregnancy.

Main Methods:

  • Review of existing clinical studies and experimental research.
  • Analysis of data on angiogenic factors in normal and complicated pregnancies.
  • Examination of preclinical models investigating interventions for angiogenic imbalances.

Main Results:

  • Substantial evidence supports the involvement of angiogenic imbalances in the pathogenesis of life-threatening pregnancy disorders.
  • The fetus appears to play a crucial role in establishing and perpetuating these angiogenic imbalances.
  • Experimental data suggest that interventions targeting angiogenic pathways may hold promise for prevention and treatment.

Conclusions:

  • Angiogenic imbalances are critical contributors to severe pregnancy complications.
  • Fetal-derived factors are likely central to the development of these imbalances.
  • Modulating angiogenesis presents a potential therapeutic strategy for improving pregnancy outcomes.