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Published on: September 9, 2012

Study of clinical characteristics, presentation, and complications among patients with congenital coagulation

Enas T Abdul-Karim1, Saad F Mohammed

  • 1Department of Community Medicine, College of Medicine, Al-Nahrain University, PO Box 14222, Baghdad, Iraq. enas_yhy@yahoo.com

Saudi Medical Journal
|March 17, 2010
PubMed

Insights

Congenital coagulation disorders, primarily Hemophilia and Von Willebrand Disease (VWD), often manifest symptoms in infancy. Early diagnosis and management are crucial for preventing complications like joint limitations in affected children.

Area of Science:

  • Hematology
  • Pediatric Medicine
  • Genetics

Background:

  • Congenital coagulation disorders are inherited conditions affecting blood clotting.
  • These disorders can lead to significant bleeding complications if not managed properly.
  • Understanding the clinical characteristics is vital for timely diagnosis and treatment.

Purpose of the Study:

  • To investigate the clinical features, presentations, and complications of congenital coagulation disorders.
  • To analyze patient data from a specialized center in Baghdad, Iraq.
  • To identify common disorders and symptom onset patterns.

Main Methods:

  • A cross-sectional study involving 243 patients with congenital coagulation disorders.
  • Data collected via structured questionnaires and physical examinations.
  • Study conducted at the Congenital Coagulation Disorders Center, Baghdad, Iraq (March-August 2008).

Main Results:

  • Hemophilia and Von Willebrand Disease (VWD) accounted for 90.1% of cases.
  • 82.7% of patients experienced symptom onset within the first year of life.
  • Hemarthroses and joint limitations were common, particularly in hemophiliacs.

Conclusions:

  • Hemophilia is a predominant diagnosis among patients studied.
  • Symptom onset typically occurs between 6-12 months, with diagnosis often within a month.
  • Approximately 50% of hemophiliacs experienced limitations in three or more joints.
Abstract

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